Synthesis and Biological Evaluation of Schiff Base and 4-thiazolidinones of Amino Salicylic Acid and Their Derivatives as an A

Schiff base, azetidinone and 4-thiazolidinone derivatives of para aminosalicylic acid were synthesised. It was planned to employ the structure based computer aided drug designing (CADD) to Schiff base, azetidinone and 4thiazolidinoneof para aminosalicylic acid. Approach was employed to understand the probable binding of para aminosalicylic acid on the active site of AMpC enzyme of HKY28 which will suggest the better insight in the designing of novel analogues of schiff base, azetidinone and 4-thiazolidinone of para amino salicylic acid as a probable antimicrobial agent. Based on the data obtained from ligand-receptor binding studies, the novel molecules were synthesised and evaluated for antimicrobial studies.The synthesised compounds were screened for their in vitro antimicrobial activity. The structure of synthesised compounds Ia-c, IIa, IIIa have been established on the basis of their spectral (IR, H NMR and mass) data. The purity of the synthesised compounds was confirmed by TLC.